Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
ric8bSynembryn-B; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. (536 aa)    
Predicted Functional Partners:
gnal
Guanine nucleotide-binding protein G(olf) subunit alpha.
   
 
 0.800
smim15
Small integral membrane protein 15.
      
 0.799
lrrc42
Leucine-rich repeat-containing protein 42; Belongs to the LRRC42 family.
      
 0.782
tceanc2
Transcription elongation factor A N-terminal and central domain-containing protein 2.
      
 0.780
exd2
Exonuclease 3'-5' domain-containing 2.
      
 0.773
dcaf5
Ddb1 and cul4-associated factor 5.
      
 0.756
gnas
GNAS complex locus.
   
 
 0.753
nudt4b
Nudix (nucleoside diphosphate-linked moiety X)-type motif 4b.
      
 0.661
btbd11b
Ankyrin repeat and BTB/POZ domain-containing protein BTBD11-B.
      
 0.657
LOC108179047
Guanine nucleotide-binding protein G(s) subunit alpha.
   
 
 0.643
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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