Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hdrHematopoietic death receptor. (418 aa)    
Predicted Functional Partners:
tnfsf10
Tumor necrosis factor (Ligand) superfamily, member 10 like 2; Belongs to the tumor necrosis factor family.
   
 
  0.994
fadd
Fas (tnfrsf6)-associated via death domain.
    
 0.980
ripk1l
Receptor (TNFRSF)-interacting serine-threonine kinase 1,-like.
    
 0.973
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
   
 0.962
tnfrsfa
Tumor necrosis factor receptor superfamily, member a.
   
 
 0.949
tnfsf10l4
Tumor necrosis factor (ligand) superfamily, member 10-like 4; Belongs to the tumor necrosis factor family.
     
  0.876
tnfsf10l3
Tumor necrosis factor (ligand) superfamily, member 10-like 3; Belongs to the tumor necrosis factor family.
     
 0.860
tnfsf11
TNF superfamily member 11; Belongs to the tumor necrosis factor family.
     
 0.825
si:dkey-13p1.3
Si:dkey-13p1.3.
      
 0.750
allc
Allantoicase; Utilization of purines as secondary nitrogen sources, when primary sources are limiting; Belongs to the allantoicase family.
      
 0.745
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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