STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F1QCW3_DANRESi:ch211-107o10.3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (327 aa)    
Predicted Functional Partners:
aldh1a3
Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family.
  
 0.926
aldh1a2
Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family.
  
 0.926
cyp26a1
Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]
   
 
 0.921
cyp27c1
Cytochrome P450 27C1; Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4- didehydroretinal). Also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid; Belongs to the cytochrome P450 family.
   
 
  0.916
pnpla4
Patatin-like phospholipase domain-containing 4.
   
 
 0.912
aox5
Aldehyde oxidase alpha.
     
 0.908
aox6
Aldehyde oxidase beta.
     
 0.908
ccdc124
Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages.
      
 0.720
spata7
Spermatogenesis-associated 7.
      
 0.708
retsat
All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. In addition, saturates the 7-8 double bond of all-trans-retinol to produce all-trans-7,8-dihydroretinol. Can also use vitamin A2 (all-trans-3,4-didehydroretinol) as a substrate, to produce all-trans-13,14-dihydro-3,4-didehydroretinol or all-trans-7,8-dihydro- 3,4-didehydroretinol. May play a role in vitamin A metabolism.
    
 0.705
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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