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ercc6l protein (Danio rerio) - STRING interaction network
"ercc6l" - DNA excision repair protein ERCC-6-like in Danio rerio
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ercc6lDNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro) (1451 aa)    
Predicted Functional Partners:
plk1
Serine/threonine-protein kinase PLK; Polo-like kinase 1 (Drosophila) (595 aa)
     
  0.995
cdk1
Cell division control protein 2; Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily (302 aa)
     
  0.967
mad2l1
MAD2 mitotic arrest deficient-like 1 (yeast) (202 aa)
     
  0.960
casc5
Cancer susceptibility candidate 5 (1824 aa)
     
 
  0.957
SGOL1
Shugoshin-like 1 (S. pombe) (616 aa)
     
  0.955
zwilch
Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity) (583 aa)
     
 
  0.954
ndc80
Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores [...] (632 aa)
   
  0.952
bub1
BUB1 mitotic checkpoint serine/threonine kinase (1202 aa)
     
  0.948
cenpe
Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family (2690 aa)
     
  0.947
SKA2
Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] (226 aa)
     
 
  0.946
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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