Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
pdia2Protein disulfide-isomerase. (555 aa)    
Predicted Functional Partners:
pdia6
Protein disulfide isomerase family A, member 6; Belongs to the protein disulfide isomerase family.
  
0.973
txndc5
Thioredoxin domain-containing 5; Belongs to the protein disulfide isomerase family.
   
 0.935
hspa5
Immunoglobulin binding protein; Belongs to the heat shock protein 70 family.
   
 
 0.901
pdia3
Protein disulfide-isomerase.
  
0.897
ero1a
ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family.
   
 0.895
pdia4
Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family.
   
0.895
ero1b
Endoplasmic reticulum oxidoreductase beta.
   
 0.895
pdia7
Protein disulfide-isomerase.
  
0.894
hsp90b1
Heat shock protein 90, beta (Grp94), member 1.
   
 
 0.877
calr3b
Calreticulin.
   
 0.866
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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