Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prickle2aPrickle homolog 2a. (869 aa)    
Predicted Functional Partners:
vangl2
Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...]
    
 0.998
vangl1
Vang-like protein.
    
 0.997
dvl2
Dishevelled segment polarity protein 2.
    
 0.992
tbx1
T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily.
      
 0.981
dvl3a
Dishevelled segment polarity protein 3a.
    
 0.969
dvl3
Dishevelled segment polarity protein 3b.
    
 0.968
dvl1b
Dishevelled segment polarity protein 1b.
    
 0.964
ankrd6b
Ankyrin repeat domain 6b.
    
 
 0.958
prickle1a
Prickle homolog 1a.
     
  0.944
celsr1a
Cadherin EGF LAG seven-pass G-type receptor 1a; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.904
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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