| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| grap2a | ptpn11a | ENSDARP00000012720 | ENSDARP00000076040 | GRB2-related adaptor protein 2a. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.576 |
| grap2a | themis | ENSDARP00000012720 | ENSDARP00000012705 | GRB2-related adaptor protein 2a. | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family. | 0.694 |
| grap2b | ptpn11a | ENSDARP00000133722 | ENSDARP00000076040 | GRB2-related adaptor protein 2b. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.576 |
| grap2b | themis | ENSDARP00000133722 | ENSDARP00000012705 | GRB2-related adaptor protein 2b. | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family. | 0.696 |
| grb2a | grb2b | ENSDARP00000133720 | ENSDARP00000122829 | Growth factor receptor-bound protein 2a. | Growth factor receptor-bound protein 2b. | 0.904 |
| grb2a | ptpn11a | ENSDARP00000133720 | ENSDARP00000076040 | Growth factor receptor-bound protein 2a. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.896 |
| grb2a | themis | ENSDARP00000133720 | ENSDARP00000012705 | Growth factor receptor-bound protein 2a. | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family. | 0.736 |
| grb2b | grb2a | ENSDARP00000122829 | ENSDARP00000133720 | Growth factor receptor-bound protein 2b. | Growth factor receptor-bound protein 2a. | 0.904 |
| grb2b | ptpn11a | ENSDARP00000122829 | ENSDARP00000076040 | Growth factor receptor-bound protein 2b. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.933 |
| grb2b | themis | ENSDARP00000122829 | ENSDARP00000012705 | Growth factor receptor-bound protein 2b. | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family. | 0.798 |
| mmachc | themis | ENSDARP00000117903 | ENSDARP00000012705 | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family. | 0.561 |
| nkl.1 | prf1.2 | ENSDARP00000128437 | ENSDARP00000124868 | NK-lysin tandem duplicate 2. | Perforin 1.2. | 0.560 |
| nkl.1 | themis | ENSDARP00000128437 | ENSDARP00000012705 | NK-lysin tandem duplicate 2. | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family. | 0.596 |
| prf1.2 | nkl.1 | ENSDARP00000124868 | ENSDARP00000128437 | Perforin 1.2. | NK-lysin tandem duplicate 2. | 0.560 |
| prf1.2 | themis | ENSDARP00000124868 | ENSDARP00000012705 | Perforin 1.2. | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity); Belongs to the themis family. | 0.711 |
| ptpn11a | grap2a | ENSDARP00000076040 | ENSDARP00000012720 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | GRB2-related adaptor protein 2a. | 0.576 |
| ptpn11a | grap2b | ENSDARP00000076040 | ENSDARP00000133722 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | GRB2-related adaptor protein 2b. | 0.576 |
| ptpn11a | grb2a | ENSDARP00000076040 | ENSDARP00000133720 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | Growth factor receptor-bound protein 2a. | 0.896 |
| ptpn11a | grb2b | ENSDARP00000076040 | ENSDARP00000122829 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | Growth factor receptor-bound protein 2b. | 0.933 |
| ptpn11a | ptprk | ENSDARP00000076040 | ENSDARP00000117401 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | Protein tyrosine phosphatase receptor type K. | 0.417 |
