STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ndrg2Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation (By similarity). Belongs to the NDRG family. (368 aa)    
Predicted Functional Partners:
mycn
N-myc protein; May function as a transcription factor.
    
 
 0.592
plekhf2
Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
   
  
 0.583
plekhh2
Pleckstrin homology domain-containing, family H (with MyTH4 domain) member 2.
      
 0.580
ndufs1
NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.
      
 0.569
fam43a
Family with sequence similarity 43 member A.
   
  
 0.547
neurl1b
Neuralized E3 ubiquitin protein ligase 1B.
   
  
 0.544
cplx2l
Complexin 2,-like.
   
  
 0.500
cap2
Adenylyl cyclase-associated protein; Belongs to the CAP family.
    
 
 0.486
bud13
BUD13 homolog.
      
 0.480
ank3b
Ankyrin 3b.
    
 
 0.479
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.