STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lypd6Ly6/PLAUR domain-containing protein 6; Acts as an important regulator of embryogenesis through its enhancement of Wnt/beta-catenin signaling. Positively regulates Wnt/beta-catenin signaling by ensuring phosphorylation of lrp6 specifically in plasma membrane rafts and its subsequent internalization into signaling-competent vesicles. Essential for the wnt8-mediated patterning of the mesoderm and neuroectoderm during gastrulation. (174 aa)    
Predicted Functional Partners:
lrrc31
Leucine-rich repeat-containing 31.
      
 0.806
lrp6
Low density lipoprotein receptor-related protein 6.
   
  
 0.696
trpv6
Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.693
r3hdml
R3H domain-containing-like; Belongs to the CRISP family.
      
 0.647
tmem174
Transmembrane protein 174.
      
 0.644
cyp19a1a
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
   
  
 0.633
lrp5
Low density lipoprotein receptor-related protein 5.
   
  
 0.609
lrrc34
Leucine-rich repeat-containing 34.
      
 0.570
gpr156
G protein-coupled receptor 156.
   
  
 0.568
nxn
Nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway; Belongs to the nucleoredoxin family.
      
 0.556
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.