chuk protein (Danio rerio) - STRING interaction network

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chuk

Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)

Predicted Functional Partners:

ikbkg

0.998

traf6

0.998

ripk1l

0.994

ikbkb

0.994

tab2

0.993

nfkb2

0.991

tab3

0.990

akt3b

0.988

irak1

0.985

map3k14a

0.983

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
akt3b	chuk	ENSDARP00000111940	ENSDARP00000013115	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.988
akt3b	ikbkb	ENSDARP00000111940	ENSDARP00000117685	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.976
akt3b	ikbkg	ENSDARP00000111940	ENSDARP00000027612	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.891
akt3b	nfkb2	ENSDARP00000111940	ENSDARP00000121285	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	0.559
akt3b	traf6	ENSDARP00000111940	ENSDARP00000036715	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.708
chuk	akt3b	ENSDARP00000013115	ENSDARP00000111940	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.988
chuk	ikbkb	ENSDARP00000013115	ENSDARP00000117685	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.994
chuk	ikbkg	ENSDARP00000013115	ENSDARP00000027612	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.998
chuk	irak1	ENSDARP00000013115	ENSDARP00000118154	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Interleukin-1 receptor-associated kinase 1.	0.985
chuk	map3k14a	ENSDARP00000013115	ENSDARP00000125811	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Mitogen-activated protein kinase kinase kinase 14a.	0.983
chuk	nfkb2	ENSDARP00000013115	ENSDARP00000121285	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	0.991
chuk	ripk1l	ENSDARP00000013115	ENSDARP00000014604	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Receptor (TNFRSF)-interacting serine-threonine kinase 1,-like.	0.994
chuk	tab2	ENSDARP00000013115	ENSDARP00000019647	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development.	0.993
chuk	tab3	ENSDARP00000013115	ENSDARP00000083707	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like.	0.990
chuk	traf6	ENSDARP00000013115	ENSDARP00000036715	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.998
ikbkb	akt3b	ENSDARP00000117685	ENSDARP00000111940	Inhibitor of nuclear factor kappa B kinase subunit beta.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.976
ikbkb	chuk	ENSDARP00000117685	ENSDARP00000013115	Inhibitor of nuclear factor kappa B kinase subunit beta.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.994
ikbkb	ikbkg	ENSDARP00000117685	ENSDARP00000027612	Inhibitor of nuclear factor kappa B kinase subunit beta.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.997
ikbkb	irak1	ENSDARP00000117685	ENSDARP00000118154	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin-1 receptor-associated kinase 1.	0.980
ikbkb	map3k14a	ENSDARP00000117685	ENSDARP00000125811	Inhibitor of nuclear factor kappa B kinase subunit beta.	Mitogen-activated protein kinase kinase kinase 14a.	0.972

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