ccdc114 protein (Danio rerio) - STRING interaction network

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ccdc114

Coiled-coil domain-containing 114. (566 aa)

Predicted Functional Partners:

ccdc151

0.986

armc4

0.983

ttc25

0.975

efcab1

0.964

dnali1

0.942

CCDC39

0.926

dnai1.1

0.914

dnah5

0.911

ttc29

0.910

drc1

0.906

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC39	armc4	ENSDARP00000141240	ENSDARP00000071920	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Armadillo repeat-containing 4.	0.964
CCDC39	ccdc114	ENSDARP00000141240	ENSDARP00000013307	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Coiled-coil domain-containing 114.	0.926
CCDC39	ccdc151	ENSDARP00000141240	ENSDARP00000086061	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Coiled-coil domain-containing 151.	0.949
CCDC39	dnah5	ENSDARP00000141240	ENSDARP00000107046	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Dynein, axonemal, heavy chain 5.	0.919
CCDC39	dnai1.1	ENSDARP00000141240	ENSDARP00000134180	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Dynein, axonemal, intermediate chain 1, paralog 1.	0.939
CCDC39	dnali1	ENSDARP00000141240	ENSDARP00000092673	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Dynein, axonemal, light intermediate chain 1.	0.976
CCDC39	drc1	ENSDARP00000141240	ENSDARP00000061828	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Dynein regulatory complex protein 1; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.	0.973
CCDC39	efcab1	ENSDARP00000141240	ENSDARP00000081908	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	EF-hand calcium-binding domain 1.	0.846
CCDC39	ttc25	ENSDARP00000141240	ENSDARP00000075390	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility.	0.860
CCDC39	ttc29	ENSDARP00000141240	ENSDARP00000119942	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	Tetratricopeptide repeat domain 29.	0.825
armc4	CCDC39	ENSDARP00000071920	ENSDARP00000141240	Armadillo repeat-containing 4.	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.	0.964
armc4	ccdc114	ENSDARP00000071920	ENSDARP00000013307	Armadillo repeat-containing 4.	Coiled-coil domain-containing 114.	0.983
armc4	ccdc151	ENSDARP00000071920	ENSDARP00000086061	Armadillo repeat-containing 4.	Coiled-coil domain-containing 151.	0.990
armc4	dnah5	ENSDARP00000071920	ENSDARP00000107046	Armadillo repeat-containing 4.	Dynein, axonemal, heavy chain 5.	0.879
armc4	dnai1.1	ENSDARP00000071920	ENSDARP00000134180	Armadillo repeat-containing 4.	Dynein, axonemal, intermediate chain 1, paralog 1.	0.905
armc4	dnali1	ENSDARP00000071920	ENSDARP00000092673	Armadillo repeat-containing 4.	Dynein, axonemal, light intermediate chain 1.	0.940
armc4	drc1	ENSDARP00000071920	ENSDARP00000061828	Armadillo repeat-containing 4.	Dynein regulatory complex protein 1; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.	0.942
armc4	efcab1	ENSDARP00000071920	ENSDARP00000081908	Armadillo repeat-containing 4.	EF-hand calcium-binding domain 1.	0.979
armc4	ttc25	ENSDARP00000071920	ENSDARP00000075390	Armadillo repeat-containing 4.	Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility.	0.993
armc4	ttc29	ENSDARP00000071920	ENSDARP00000119942	Armadillo repeat-containing 4.	Tetratricopeptide repeat domain 29.	0.820

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