fgfr1a protein (Danio rerio) - STRING interaction network

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Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
fgf16	fgf17	ENSDARP00000061927	ENSDARP00000137629	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	0.601
fgf16	fgf1a	ENSDARP00000061927	ENSDARP00000008825	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...]	0.797
fgf16	fgf2	ENSDARP00000061927	ENSDARP00000132803	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.619
fgf16	fgf20a	ENSDARP00000061927	ENSDARP00000007295	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.418
fgf16	fgf23	ENSDARP00000061927	ENSDARP00000067387	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.853
fgf16	fgf3	ENSDARP00000061927	ENSDARP00000132485	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family.	0.764
fgf16	fgf4	ENSDARP00000061927	ENSDARP00000135882	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.554
fgf16	fgf7	ENSDARP00000061927	ENSDARP00000122453	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.869
fgf16	fgf8a	ENSDARP00000061927	ENSDARP00000018653	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis.	0.565
fgf16	fgfr1a	ENSDARP00000061927	ENSDARP00000013742	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...]	0.973
fgf17	fgf16	ENSDARP00000137629	ENSDARP00000061927	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family.	0.601
fgf17	fgf1a	ENSDARP00000137629	ENSDARP00000008825	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...]	0.755
fgf17	fgf2	ENSDARP00000137629	ENSDARP00000132803	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.470
fgf17	fgf20a	ENSDARP00000137629	ENSDARP00000007295	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
fgf17	fgf23	ENSDARP00000137629	ENSDARP00000067387	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.827
fgf17	fgf3	ENSDARP00000137629	ENSDARP00000132485	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family.	0.842
fgf17	fgf4	ENSDARP00000137629	ENSDARP00000135882	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508
fgf17	fgf7	ENSDARP00000137629	ENSDARP00000122453	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
fgf17	fgf8a	ENSDARP00000137629	ENSDARP00000018653	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis.	0.860
fgf17	fgfr1a	ENSDARP00000137629	ENSDARP00000013742	Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...]	0.975

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