Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
traf4aTNF receptor-associated factor. (470 aa)    
Predicted Functional Partners:
usp7
Ubiquitin-specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.
    
 0.959
traf6
TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.
    
 
0.945
ncf1
Neutrophil cytosolic factor 1.
   
 
 0.913
traf3ip2l
TRAF3-interacting protein 2-like.
    
 0.872
Traf3ip2b
SEFIR domain-containing protein.
    
 0.872
map3k5
Mitogen-activated protein kinase kinase kinase 5.
    
 0.844
ENSDARP00000146561
Si:ch211-1i11.3.
    
 0.844
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
    
 0.836
irak4
Interleukin-1 receptor-associated kinase 4.
   
 0.807
map3k4
Mitogen-activated protein kinase kinase kinase 4.
    
 
 0.794
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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