STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
traf4aTNF receptor-associated factor. (470 aa)    
Predicted Functional Partners:
irak4
Interleukin-1 receptor-associated kinase 4.
   
 
 0.860
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response.
   
 
 0.775
ncf1
Neutrophil cytosolic factor 1.
   
 
 0.765
irak1
Interleukin-1 receptor-associated kinase 1.
   
 
 0.701
tradd
Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
    
 
 0.689
dhrs11a
Dehydrogenase/reductase (SDR family) member 11a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.619
dhrs11b
Dehydrogenase/reductase (SDR family) member 11b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.617
tlcd1
TLC domain-containing 1.
      
 0.612
irak3
Interleukin-1 receptor-associated kinase 3.
   
 
 0.593
smurf1
E3 ubiquitin-protein ligase.
    
 
 0.589
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.