node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HACD4 | hsd17b12a | ENSDARP00000132812 | ENSDARP00000014003 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.958 |
cyp19a1a | cyp1a | ENSDARP00000111604 | ENSDARP00000139599 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | 0.960 |
cyp19a1a | cyp1b1 | ENSDARP00000111604 | ENSDARP00000107132 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.636 |
cyp19a1a | hsd17b1 | ENSDARP00000111604 | ENSDARP00000026566 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.988 |
cyp19a1a | hsd17b12a | ENSDARP00000111604 | ENSDARP00000014003 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.962 |
cyp19a1a | hsd17b7 | ENSDARP00000111604 | ENSDARP00000098015 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.959 |
cyp19a1a | hsd17b8 | ENSDARP00000111604 | ENSDARP00000001459 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.944 |
cyp1a | cyp19a1a | ENSDARP00000139599 | ENSDARP00000111604 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.960 |
cyp1a | cyp1b1 | ENSDARP00000139599 | ENSDARP00000107132 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.931 |
cyp1a | hsd17b1 | ENSDARP00000139599 | ENSDARP00000026566 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.927 |
cyp1a | hsd17b12a | ENSDARP00000139599 | ENSDARP00000014003 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.934 |
cyp1a | hsd17b7 | ENSDARP00000139599 | ENSDARP00000098015 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.939 |
cyp1a | hsd17b8 | ENSDARP00000139599 | ENSDARP00000001459 | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.928 |
cyp1b1 | cyp19a1a | ENSDARP00000107132 | ENSDARP00000111604 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.636 |
cyp1b1 | cyp1a | ENSDARP00000107132 | ENSDARP00000139599 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. | 0.931 |
cyp1b1 | hsd17b1 | ENSDARP00000107132 | ENSDARP00000026566 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.938 |
cyp1b1 | hsd17b12a | ENSDARP00000107132 | ENSDARP00000014003 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.939 |
cyp1b1 | hsd17b7 | ENSDARP00000107132 | ENSDARP00000098015 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 7. | 0.932 |
cyp1b1 | hsd17b8 | ENSDARP00000107132 | ENSDARP00000001459 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.935 |
hacd1 | hsd17b12a | ENSDARP00000138307 | ENSDARP00000014003 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Very-long-chain 3-oxoacyl-CoA reductase-A; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of memb [...] | 0.958 |