Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rdh14bRetinol dehydrogenase 14b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)    
Predicted Functional Partners:
porb
NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
      
 0.800
cyp2k6
Cytochrome P450 2K6; Metabolizes aflatoxin B1 (AFB1) to the cytotoxic derivative AFB1 exo-8,9-epoxide. Does not show activity towards lauric acid.
   
 
 0.711
cyp2k31
Cytochrome P450 2K6; Belongs to the cytochrome P450 family.
   
 
 0.710
adh8b
Mixed alcohol dehydrogenase Adh8b.
    
 0.687
crabp1b
Cellular retinoic acid-binding protein type I; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
      
 0.600
Q29RF1_DANRE
Si:ch211-195d17.2 protein.
    
 
 0.591
adh5
S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
    
 0.583
vtg3
Vitellogenin 3, phosvitinless.
    
 
 0.547
scd
Stearoyl-CoA desaturase (delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family.
    
 0.526
nots
Nothepsin; Belongs to the peptidase A1 family.
    
 
 0.522
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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