Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
si:dkey-32n7.4Si:dkey-32n7.4; Belongs to the integrin alpha chain family. (1136 aa)    
Predicted Functional Partners:
itgb2
Integrin beta.
   
 0.993
jam3b
Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes.
    
  0.934
crkl
V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.
     
 0.873
crk
V-crk sarcoma virus CT10 oncogene homolog (Avian).
     
 0.873
src
Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...]
    
  0.873
bcar1
BCAR1 scaffold protein, Cas family member.
     
  0.871
fn1a
Fibronectin 1a.
    
  0.871
jam3a
Junctional adhesion molecule 3a.
    
  0.865
fga
Fibrinogen alpha chain.
    
 0.857
fgb
Fibrinogen, B beta polypeptide.
    
 0.853
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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