STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgrmc2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (201 aa)    
Predicted Functional Partners:
paqr7a
Progestin and adipoQ receptor family member VII, a.
    
 
 0.880
paqr7b
Membrane progestin receptor alpha-B; Steroid membrane receptor. Signals upon progestin binding, resulting in rapid activation of MAPK and down-regulation of adenylyl cyclase activity. Interacts with steroids with varying degrees of affinity, showing specificity for activation by the maturation-inducing steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Capable of mediating progestin-induced oocyte maturation.
    
 
 0.876
cyb5b
Cytochrome b5 type B; Belongs to the cytochrome b5 family.
   
  
 0.874
cyb5a
Cytochrome b5 type A (microsomal); Belongs to the cytochrome b5 family.
   
  
 0.873
pgr
Progesterone receptor.
      
 0.807
paqr5a
Membrane progestin receptor gamma-A; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity); Belongs to the ADIPOR family.
    
 
 0.752
larp1b
La ribonucleoprotein 1B.
   
 
 0.740
aaas
Achalasia, adrenocortical insufficiency, alacrimia.
      
 0.716
paqr5b
Membrane progestin receptor gamma-B; Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity). Belongs to the ADIPOR family.
    
 
 0.671
lhcgr
Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
      
 0.668
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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