Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pgrmc2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (201 aa)    
Predicted Functional Partners:
pgrmc1
Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family.
   
 0.956
tmem97
Transmembrane protein 97.
     
 0.955
cyb5b
Cytochrome b5 type B; Belongs to the cytochrome b5 family.
   
  
 0.866
pgr
Progesterone receptor.
    
 
 0.863
cyb5a
Cytochrome b5 type A (microsomal); Belongs to the cytochrome b5 family.
   
  
 0.859
paqr7b
Membrane progestin receptor alpha-B; Steroid membrane receptor. Signals upon progestin binding, resulting in rapid activation of MAPK and down-regulation of adenylyl cyclase activity. Interacts with steroids with varying degrees of affinity, showing specificity for activation by the maturation-inducing steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Capable of mediating progestin-induced oocyte maturation.
   
 
 0.821
paqr7a
Progestin and adipoQ receptor family member VII, a.
   
 
 0.820
nenf
Neudesin neurotrophic factor; Belongs to the cytochrome b5 family.
   
 
0.815
fech
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
    
 
 0.748
tent2
Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. May not play a role in replication-dependent histone mRNA degradation (By similarity). Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
     
 0.742
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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