Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ela3lElastase 3-like; Belongs to the peptidase S1 family. (269 aa)    
Predicted Functional Partners:
fabp10a
Fatty acid-binding protein 10-A, liver basic; Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Binds one cholate per subunit.
   
  
 0.944
cpa5
Carboxypeptidase A5.
   
 
 0.789
cpa4
Carboxypeptidase A4.
   
 
 0.738
ptf1a
Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
   
  
 0.724
cel.1
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
   
 0.692
cpa1
Carboxypeptidase A1 (pancreatic).
   
 
 0.633
amy2a
Alpha-amylase.
   
 
 0.595
gcga
Glucagon a.
   
  
 0.585
cpb1
Carboxypeptidase B1 (tissue).
   
 
 0.568
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.559
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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