Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
map2k2aMitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)    
Predicted Functional Partners:
mapk1
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.997
map2k1
Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.
  
 
0.991
mapk3
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.991
braf
B-Raf proto-oncogene, serine/threonine kinase.
   
0.988
lamtor3
Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
   
 0.988
araf
A-Raf proto-oncogene, serine/threonine kinase.
   
0.987
map3k8
Mitogen-activated protein kinase kinase kinase 8.
  
0.982
mos
V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily.
    
  0.953
raf1a
Raf-1 proto-oncogene, serine/threonine kinase a.
   
0.950
raf1a-2
Raf-1 proto-oncogene, serine/threonine kinase a.
   
 0.944
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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