node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ahr1a | hsp90ab1 | ENSDARP00000017676 | ENSDARP00000014978 | Aryl hydrocarbon receptor 1a. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.918 |
ahr1a | ptges3a | ENSDARP00000017676 | ENSDARP00000054236 | Aryl hydrocarbon receptor 1a. | Prostaglandin E synthase 3a (cytosolic). | 0.891 |
cdc37 | hsp70.3 | ENSDARP00000131796 | ENSDARP00000010413 | Cell division cycle 37 homolog (S. cerevisiae). | Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. | 0.808 |
cdc37 | hsp90ab1 | ENSDARP00000131796 | ENSDARP00000014978 | Cell division cycle 37 homolog (S. cerevisiae). | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.970 |
cdc37 | hspa8 | ENSDARP00000131796 | ENSDARP00000090766 | Cell division cycle 37 homolog (S. cerevisiae). | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.401 |
cdc37 | ptges3a | ENSDARP00000131796 | ENSDARP00000054236 | Cell division cycle 37 homolog (S. cerevisiae). | Prostaglandin E synthase 3a (cytosolic). | 0.682 |
cdc37 | ripk3 | ENSDARP00000131796 | ENSDARP00000110955 | Cell division cycle 37 homolog (S. cerevisiae). | Receptor-interacting serine-threonine kinase 3. | 0.623 |
cdc37 | stip1 | ENSDARP00000131796 | ENSDARP00000100503 | Cell division cycle 37 homolog (S. cerevisiae). | Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein). | 0.843 |
cdc37 | sugt1 | ENSDARP00000131796 | ENSDARP00000135565 | Cell division cycle 37 homolog (S. cerevisiae). | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. | 0.473 |
hsp70.3 | cdc37 | ENSDARP00000010413 | ENSDARP00000131796 | Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. | Cell division cycle 37 homolog (S. cerevisiae). | 0.808 |
hsp70.3 | hsp90ab1 | ENSDARP00000010413 | ENSDARP00000014978 | Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.945 |
hsp70.3 | hspa8 | ENSDARP00000010413 | ENSDARP00000090766 | Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.413 |
hsp70.3 | ptges3a | ENSDARP00000010413 | ENSDARP00000054236 | Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. | Prostaglandin E synthase 3a (cytosolic). | 0.704 |
hsp70.3 | stip1 | ENSDARP00000010413 | ENSDARP00000100503 | Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. | Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein). | 0.911 |
hsp90ab1 | ahr1a | ENSDARP00000014978 | ENSDARP00000017676 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Aryl hydrocarbon receptor 1a. | 0.918 |
hsp90ab1 | cdc37 | ENSDARP00000014978 | ENSDARP00000131796 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Cell division cycle 37 homolog (S. cerevisiae). | 0.970 |
hsp90ab1 | hsp70.3 | ENSDARP00000014978 | ENSDARP00000010413 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. | 0.945 |
hsp90ab1 | hspa8 | ENSDARP00000014978 | ENSDARP00000090766 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.931 |
hsp90ab1 | mos | ENSDARP00000014978 | ENSDARP00000092499 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. | 0.915 |
hsp90ab1 | ptges3a | ENSDARP00000014978 | ENSDARP00000054236 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Prostaglandin E synthase 3a (cytosolic). | 0.985 |