Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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hsp90ab1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (725 aa)    
Predicted Functional Partners:
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.
   
 0.999
hsp90b1
Heat shock protein 90, beta (Grp94), member 1.
   
 0.991
stip1
Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein).
   
 0.981
ahr2
Aryl hydrocarbon receptor 2.
    
 0.980
ahr1b
Aryl hydrocarbon receptor 1B.
    
 0.979
hspd1
Heat shock 60kD protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family.
   
 0.979
hsp90aa1.2
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.
  
  
0.973
ptges3a
Prostaglandin E synthase 3a (cytosolic).
   
 0.964
ar
Androgen receptor.
    
 0.963
hspa8
Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]
   
 0.962
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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