| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| atm | atr | ENSDARP00000015167 | ENSDARP00000118304 | Non-specific serine/threonine protein kinase. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.998 |
| atm | chek1 | ENSDARP00000015167 | ENSDARP00000133390 | Non-specific serine/threonine protein kinase. | CHK1 checkpoint homolog (S. pombe); Belongs to the protein kinase superfamily. | 0.999 |
| atm | chek2 | ENSDARP00000015167 | ENSDARP00000036490 | Non-specific serine/threonine protein kinase. | Checkpoint kinase 2. | 0.999 |
| atm | mdm2 | ENSDARP00000015167 | ENSDARP00000072320 | Non-specific serine/threonine protein kinase. | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. | 0.989 |
| atm | mre11a | ENSDARP00000015167 | ENSDARP00000139437 | Non-specific serine/threonine protein kinase. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.999 |
| atm | nbn | ENSDARP00000015167 | ENSDARP00000058973 | Non-specific serine/threonine protein kinase. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity (By similarity). | 0.999 |
| atm | rad50 | ENSDARP00000015167 | ENSDARP00000124284 | Non-specific serine/threonine protein kinase. | RAD50 homolog, double strand break repair protein. | 0.999 |
| atm | tp53 | ENSDARP00000015167 | ENSDARP00000116736 | Non-specific serine/threonine protein kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.999 |
| atm | tp53bp1 | ENSDARP00000015167 | ENSDARP00000101125 | Non-specific serine/threonine protein kinase. | Tumor protein p53-binding protein, 1. | 0.993 |
| atm | wrn | ENSDARP00000015167 | ENSDARP00000133164 | Non-specific serine/threonine protein kinase. | WRN RecQ-like helicase. | 0.993 |
| atr | atm | ENSDARP00000118304 | ENSDARP00000015167 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Non-specific serine/threonine protein kinase. | 0.998 |
| atr | chek1 | ENSDARP00000118304 | ENSDARP00000133390 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | CHK1 checkpoint homolog (S. pombe); Belongs to the protein kinase superfamily. | 0.999 |
| atr | chek2 | ENSDARP00000118304 | ENSDARP00000036490 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Checkpoint kinase 2. | 0.998 |
| atr | mre11a | ENSDARP00000118304 | ENSDARP00000139437 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.945 |
| atr | nbn | ENSDARP00000118304 | ENSDARP00000058973 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity (By similarity). | 0.973 |
| atr | rad50 | ENSDARP00000118304 | ENSDARP00000124284 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | RAD50 homolog, double strand break repair protein. | 0.944 |
| atr | tp53 | ENSDARP00000118304 | ENSDARP00000116736 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. | 0.998 |
| atr | tp53bp1 | ENSDARP00000118304 | ENSDARP00000101125 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Tumor protein p53-binding protein, 1. | 0.983 |
| atr | wrn | ENSDARP00000118304 | ENSDARP00000133164 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | WRN RecQ-like helicase. | 0.968 |
| chek1 | atm | ENSDARP00000133390 | ENSDARP00000015167 | CHK1 checkpoint homolog (S. pombe); Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase. | 0.999 |
