Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cela1.6Chymotrypsin-like elastase family member 1, tandem duplicate 6; Belongs to the peptidase S1 family. (266 aa)    
Predicted Functional Partners:
gsdmea
Gasdermin Ea.
      
 0.662
cpa4
Carboxypeptidase A4.
   
 
 0.648
f13a1b
Coagulation factor XIII, A1 polypeptide b.
    
 0.621
pjvk
Pejvakin.
      
 0.597
caspb
Caspase b subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form following the recruitment of caspase caspa. Its subsequent activation causes the cleavage of the midformed pro-il1b and results in il1b maturation and secretion in the extracellular milieu. [...]
    
 0.566
gsdmeb
Deafness, autosomal dominant 5.
      
 0.561
ela3l
Elastase 3-like; Belongs to the peptidase S1 family.
  
   
0.547
cpa5
Carboxypeptidase A5.
   
 
 0.483
cpa1
Carboxypeptidase A1 (pancreatic).
   
 
 0.482
fn1b
Fibronectin 1b.
   
 0.466
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.