stk3 protein (Danio rerio) - STRING interaction network

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stk3

Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...] (492 aa)

Predicted Functional Partners:

sav1

0.999

mob1ba

0.996

RASSF5

0.995

rassf1

0.993

rassf6

0.989

casp3a

0.988

lats2

0.987

mob1a

0.985

wwtr1

0.983

lats1

0.977

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RASSF5	mob1a	ENSDARP00000074501	ENSDARP00000141585	Si:dkey-85p17.3.	MOB kinase activator 1A.	0.572
RASSF5	mob1ba	ENSDARP00000074501	ENSDARP00000088385	Si:dkey-85p17.3.	MOB1, Mps One Binder kinase activator-like 1A (Yeast).	0.645
RASSF5	rassf1	ENSDARP00000074501	ENSDARP00000119596	Si:dkey-85p17.3.	Ras association domain family member 1.	0.994
RASSF5	sav1	ENSDARP00000074501	ENSDARP00000025090	Si:dkey-85p17.3.	Salvador family WW domain-containing protein 1.	0.775
RASSF5	stk3	ENSDARP00000074501	ENSDARP00000015367	Si:dkey-85p17.3.	Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...]	0.995
casp3a	sav1	ENSDARP00000006831	ENSDARP00000025090	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Salvador family WW domain-containing protein 1.	0.750
casp3a	stk3	ENSDARP00000006831	ENSDARP00000015367	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...]	0.988
lats1	mob1a	ENSDARP00000027561	ENSDARP00000141585	LATS, large tumor suppressor, homolog 1 (Drosophila).	MOB kinase activator 1A.	0.960
lats1	mob1ba	ENSDARP00000027561	ENSDARP00000088385	LATS, large tumor suppressor, homolog 1 (Drosophila).	MOB1, Mps One Binder kinase activator-like 1A (Yeast).	0.927
lats1	rassf1	ENSDARP00000027561	ENSDARP00000119596	LATS, large tumor suppressor, homolog 1 (Drosophila).	Ras association domain family member 1.	0.641
lats1	sav1	ENSDARP00000027561	ENSDARP00000025090	LATS, large tumor suppressor, homolog 1 (Drosophila).	Salvador family WW domain-containing protein 1.	0.998
lats1	stk3	ENSDARP00000027561	ENSDARP00000015367	LATS, large tumor suppressor, homolog 1 (Drosophila).	Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...]	0.977
lats1	wwtr1	ENSDARP00000027561	ENSDARP00000088304	LATS, large tumor suppressor, homolog 1 (Drosophila).	WW domain-containing transcription regulator 1.	0.990
lats2	mob1a	ENSDARP00000114142	ENSDARP00000141585	Large tumor suppressor kinase 2.	MOB kinase activator 1A.	0.919
lats2	mob1ba	ENSDARP00000114142	ENSDARP00000088385	Large tumor suppressor kinase 2.	MOB1, Mps One Binder kinase activator-like 1A (Yeast).	0.986
lats2	rassf1	ENSDARP00000114142	ENSDARP00000119596	Large tumor suppressor kinase 2.	Ras association domain family member 1.	0.584
lats2	sav1	ENSDARP00000114142	ENSDARP00000025090	Large tumor suppressor kinase 2.	Salvador family WW domain-containing protein 1.	0.995
lats2	stk3	ENSDARP00000114142	ENSDARP00000015367	Large tumor suppressor kinase 2.	Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...]	0.987
lats2	wwtr1	ENSDARP00000114142	ENSDARP00000088304	Large tumor suppressor kinase 2.	WW domain-containing transcription regulator 1.	0.995
mob1a	RASSF5	ENSDARP00000141585	ENSDARP00000074501	MOB kinase activator 1A.	Si:dkey-85p17.3.	0.572

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