node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adad1 | esrp2 | ENSDARP00000157152 | ENSDARP00000015568 | Adenosine deaminase domain-containing 1 (testis-specific). | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | 0.535 |
arhgef10lb | esrp2 | ENSDARP00000121072 | ENSDARP00000015568 | Rho guanine nucleotide exchange factor (GEF) 10-like b. | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | 0.598 |
arhgef10lb | fam172a | ENSDARP00000121072 | ENSDARP00000069087 | Rho guanine nucleotide exchange factor (GEF) 10-like b. | Cotranscriptional regulator FAM172A homolog; May play role in the regulation of alternative splicing. May have hydrolase activity; Belongs to the FAM172 family. | 0.480 |
commd4 | esrp2 | ENSDARP00000110023 | ENSDARP00000015568 | COMM domain-containing 4. | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | 0.649 |
commd4 | mbnl1 | ENSDARP00000110023 | ENSDARP00000088834 | COMM domain-containing 4. | Muscleblind-like-splicing regulator 1. | 0.452 |
enah | esrp2 | ENSDARP00000019206 | ENSDARP00000015568 | ENAH actin regulator. | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | 0.591 |
enah | phactr4b | ENSDARP00000019206 | ENSDARP00000044234 | ENAH actin regulator. | Phosphatase and actin regulator 4B; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). | 0.452 |
esrp2 | adad1 | ENSDARP00000015568 | ENSDARP00000157152 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | Adenosine deaminase domain-containing 1 (testis-specific). | 0.535 |
esrp2 | arhgef10lb | ENSDARP00000015568 | ENSDARP00000121072 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | Rho guanine nucleotide exchange factor (GEF) 10-like b. | 0.598 |
esrp2 | commd4 | ENSDARP00000015568 | ENSDARP00000110023 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | COMM domain-containing 4. | 0.649 |
esrp2 | enah | ENSDARP00000015568 | ENSDARP00000019206 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | ENAH actin regulator. | 0.591 |
esrp2 | fam172a | ENSDARP00000015568 | ENSDARP00000069087 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | Cotranscriptional regulator FAM172A homolog; May play role in the regulation of alternative splicing. May have hydrolase activity; Belongs to the FAM172 family. | 0.537 |
esrp2 | fgfr2 | ENSDARP00000015568 | ENSDARP00000124472 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.671 |
esrp2 | mbnl1 | ENSDARP00000015568 | ENSDARP00000088834 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | Muscleblind-like-splicing regulator 1. | 0.516 |
esrp2 | phactr4b | ENSDARP00000015568 | ENSDARP00000044234 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | Phosphatase and actin regulator 4B; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). | 0.530 |
esrp2 | rbm10 | ENSDARP00000015568 | ENSDARP00000148117 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | RNA-binding motif protein 10. | 0.633 |
esrp2 | rbm47 | ENSDARP00000015568 | ENSDARP00000116938 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | RNA-binding motif protein 47. | 0.641 |
fam172a | arhgef10lb | ENSDARP00000069087 | ENSDARP00000121072 | Cotranscriptional regulator FAM172A homolog; May play role in the regulation of alternative splicing. May have hydrolase activity; Belongs to the FAM172 family. | Rho guanine nucleotide exchange factor (GEF) 10-like b. | 0.480 |
fam172a | esrp2 | ENSDARP00000069087 | ENSDARP00000015568 | Cotranscriptional regulator FAM172A homolog; May play role in the regulation of alternative splicing. May have hydrolase activity; Belongs to the FAM172 family. | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity). | 0.537 |
fam172a | rbm10 | ENSDARP00000069087 | ENSDARP00000148117 | Cotranscriptional regulator FAM172A homolog; May play role in the regulation of alternative splicing. May have hydrolase activity; Belongs to the FAM172 family. | RNA-binding motif protein 10. | 0.601 |