| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C11H6orf120 | erlin1 | ENSDARP00000014999 | ENSDARP00000015815 | UPF0669 protein C6orf120 homolog. | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | 0.643 |
| C11H6orf120 | rnf170 | ENSDARP00000014999 | ENSDARP00000149585 | UPF0669 protein C6orf120 homolog. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor (ITPR) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR turnover in resting cells. | 0.726 |
| C11H6orf120 | rnf185 | ENSDARP00000014999 | ENSDARP00000046780 | UPF0669 protein C6orf120 homolog. | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | 0.501 |
| C11H6orf120 | tmub1 | ENSDARP00000014999 | ENSDARP00000056641 | UPF0669 protein C6orf120 homolog. | Transmembrane and ubiquitin-like domain-containing protein 1; May contribute to the regulation of translation during cell- cycle progression. May contribute to the regulation of cell proliferation (By similarity). The membrane form is involved in sterol- regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. May be involved in centrosome assembly. | 0.732 |
| erlin1 | C11H6orf120 | ENSDARP00000015815 | ENSDARP00000014999 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | UPF0669 protein C6orf120 homolog. | 0.643 |
| erlin1 | faf2 | ENSDARP00000015815 | ENSDARP00000033367 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | Fas-associated factor family member 2. | 0.681 |
| erlin1 | nt5c2a | ENSDARP00000015815 | ENSDARP00000057573 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | 5'-nucleotidase, cytosolic IIa. | 0.668 |
| erlin1 | nt5c2l1 | ENSDARP00000015815 | ENSDARP00000020283 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | 5'-nucleotidase, cytosolic II,-like 1. | 0.662 |
| erlin1 | os9 | ENSDARP00000015815 | ENSDARP00000120218 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | OS9 endoplasmic reticulum lectin. | 0.650 |
| erlin1 | rnf170 | ENSDARP00000015815 | ENSDARP00000149585 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor (ITPR) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR turnover in resting cells. | 0.912 |
| erlin1 | rnf185 | ENSDARP00000015815 | ENSDARP00000046780 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | 0.818 |
| erlin1 | scap | ENSDARP00000015815 | ENSDARP00000121892 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | SREBF chaperone. | 0.665 |
| erlin1 | tmub1 | ENSDARP00000015815 | ENSDARP00000056641 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | Transmembrane and ubiquitin-like domain-containing protein 1; May contribute to the regulation of translation during cell- cycle progression. May contribute to the regulation of cell proliferation (By similarity). The membrane form is involved in sterol- regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. May be involved in centrosome assembly. | 0.858 |
| erlin1 | vcp | ENSDARP00000015815 | ENSDARP00000012048 | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] | 0.649 |
| faf2 | erlin1 | ENSDARP00000033367 | ENSDARP00000015815 | Fas-associated factor family member 2. | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | 0.681 |
| faf2 | os9 | ENSDARP00000033367 | ENSDARP00000120218 | Fas-associated factor family member 2. | OS9 endoplasmic reticulum lectin. | 0.764 |
| faf2 | vcp | ENSDARP00000033367 | ENSDARP00000012048 | Fas-associated factor family member 2. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] | 0.974 |
| nt5c2a | erlin1 | ENSDARP00000057573 | ENSDARP00000015815 | 5'-nucleotidase, cytosolic IIa. | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | 0.668 |
| nt5c2a | nt5c2l1 | ENSDARP00000057573 | ENSDARP00000020283 | 5'-nucleotidase, cytosolic IIa. | 5'-nucleotidase, cytosolic II,-like 1. | 0.915 |
| nt5c2l1 | erlin1 | ENSDARP00000020283 | ENSDARP00000015815 | 5'-nucleotidase, cytosolic II,-like 1. | Erlin-1; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family. | 0.662 |
