Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
map4k2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (865 aa)    
Predicted Functional Partners:
traf2b
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
  0.952
traf2a
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
  0.937
map4k6
Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
     
  0.934
unm_sa808
Un-named sa808.
   
  0.878
dicp2.2
Diverse immunoglobulin domain-containing protein 2.2.
      
 0.775
map3k1
Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
   
  0.752
dicp2.1
Diverse immunoglobulin domain-containing protein 2.1.
      
 0.737
wwc3
WWC family member 3.
      
 0.734
map4k5
Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
     
  0.723
map4k3a
Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
     
  0.723
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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