node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arl6 | msx1b | ENSDARP00000046093 | ENSDARP00000015954 | ADP-ribosylation factor-like protein 6; Probably involved in membrane protein trafficking at the base of the ciliary organelle. May function in cilia biogenesis. Isoform 2 is required for proper retinal function and organization. Belongs to the small GTPase superfamily. Arf family. | Homeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. | 0.560 |
crestin | foxd3 | ENSDARP00000142925 | ENSDARP00000107660 | Crestin. | Forkhead box D3. | 0.857 |
crestin | msx1b | ENSDARP00000142925 | ENSDARP00000015954 | Crestin. | Homeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. | 0.481 |
crestin | tfap2a | ENSDARP00000142925 | ENSDARP00000157668 | Crestin. | Transcription factor AP-2 alpha. | 0.645 |
fgf20a | fgfr1a | ENSDARP00000007295 | ENSDARP00000013742 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.953 |
fgf20a | lef1 | ENSDARP00000007295 | ENSDARP00000114249 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Lymphocyte enhancer binding factor 1 Lef1. | 0.443 |
fgf20a | msx1b | ENSDARP00000007295 | ENSDARP00000015954 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Homeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. | 0.862 |
fgf20a | shha | ENSDARP00000007295 | ENSDARP00000125090 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.492 |
fgf20a | wnt10a | ENSDARP00000007295 | ENSDARP00000005680 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development. Regulates the expression of genes involved in tooth development. Belongs to the Wnt family. | 0.490 |
fgfr1a | fgf20a | ENSDARP00000013742 | ENSDARP00000007295 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.953 |
fgfr1a | lef1 | ENSDARP00000013742 | ENSDARP00000114249 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Lymphocyte enhancer binding factor 1 Lef1. | 0.477 |
fgfr1a | msx1b | ENSDARP00000013742 | ENSDARP00000015954 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Homeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. | 0.553 |
fgfr1a | shha | ENSDARP00000013742 | ENSDARP00000125090 | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.725 |
foxd3 | crestin | ENSDARP00000107660 | ENSDARP00000142925 | Forkhead box D3. | Crestin. | 0.857 |
foxd3 | lef1 | ENSDARP00000107660 | ENSDARP00000114249 | Forkhead box D3. | Lymphocyte enhancer binding factor 1 Lef1. | 0.465 |
foxd3 | msx1b | ENSDARP00000107660 | ENSDARP00000015954 | Forkhead box D3. | Homeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. | 0.471 |
foxd3 | shha | ENSDARP00000107660 | ENSDARP00000125090 | Forkhead box D3. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.517 |
foxd3 | tfap2a | ENSDARP00000107660 | ENSDARP00000157668 | Forkhead box D3. | Transcription factor AP-2 alpha. | 0.866 |
foxd3 | twist1b | ENSDARP00000107660 | ENSDARP00000052926 | Forkhead box D3. | Twist family bHLH transcription factor 1b. | 0.571 |
lef1 | fgf20a | ENSDARP00000114249 | ENSDARP00000007295 | Lymphocyte enhancer binding factor 1 Lef1. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.443 |