Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
stam2Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2. (509 aa)    
Predicted Functional Partners:
stam
Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1.
  
0.999
hgs
Hepatocyte growth factor-regulated tyrosine kinase substrate.
   
0.999
usp8
Ubiquitin-specific peptidase 8; Belongs to the peptidase C19 family.
    
 
 0.958
ptpn23a
Protein tyrosine phosphatase, non-receptor type 23, a.
   
 
 0.923
ptpn23b
Protein tyrosine phosphatase, non-receptor type 23, b.
   
 
 0.923
stambpa
STAM-binding protein-like A; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity).
   
 
 0.855
tyk2
Tyrosine-protein kinase.
    
 0.830
mrc1a
Mannose receptor, C type 1a.
     
  0.813
rnf11b
Ring finger protein 11b.
    
 
 0.800
vps37a
Vacuolar protein sorting 37A.
   
 
 0.798
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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