STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plxnb3Plexin B3. (1886 aa)    
Predicted Functional Partners:
sema5a
Semaphorin-5A.
    
 0.991
plxnd1
Plexin D1.
    
0.767
sema4d
Uncharacterized protein; Belongs to the semaphorin family.
    
 
 0.760
sema6bb
Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb.
    
 
 0.722
plxnc1
Plexin C1.
    
0.634
SEMA4F
Ssemaphorin 4F; Belongs to the semaphorin family.
    
 
 0.599
plxna2
Plexin A2.
   
0.596
plxna4
Plexin-A4; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons.
   
0.595
plxna3
Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
   
0.590
sema7a
Semaphorin 7A; Belongs to the semaphorin family.
    
 
 0.578
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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