STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hpda4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. (397 aa)    
Predicted Functional Partners:
hgd
Homogentisate 1,2-dioxygenase.
  
 0.999
tat
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
   
 
 0.990
got2b
Aspartate aminotransferase.
  
 
 0.962
got2a
Aspartate aminotransferase.
  
 
 0.962
got1
Aspartate aminotransferase.
  
 
 0.962
got1l1
Glutamic-oxaloacetic transaminase 1-like 1.
  
 
 0.956
mif
Macrophage migration inhibitory factor.
   
 
 0.912
hpdb
4-hydroxyphenylpyruvate dioxygenase.
  
 
 
0.907
fah
Fumarylacetoacetase.
 
  
 0.906
F1QRA1_DANRE
Amine oxidase.
   
  0.901
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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