STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hpda4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine (388 aa)    
Predicted Functional Partners:
hgd
Homogentisate 1,2-dioxygenase
  
 0.999
tat
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate
   
 
 0.999
got1
Aspartate aminotransferase, cytoplasmic; Aspartate aminotransferase; Glutamic-oxaloacetic transaminase 1, soluble
  
 
 0.955
got2b
Aspartate aminotransferase; Glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)
    
 0.954
got2a
Aspartate aminotransferase; Glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)
    
 0.954
got1l1
Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1-like 1
  
 
 0.943
IL4I1
L-amino-acid oxidase; Amine oxidase; Interleukin 4 induced 1
    
 0.918
mif
Macrophage migration inhibitory factor
   
 
 0.910
fah
Fumarylacetoacetate hydrolase (fumarylacetoacetase)
 
  
 0.826
prcc
Papillary renal cell carcinoma (translocation-associated)
      
 0.822
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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