Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hpda4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. (397 aa)    
Predicted Functional Partners:
hgd
Homogentisate 1,2-dioxygenase.
  
 0.998
tat
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
   
 
 0.992
got1
Aspartate aminotransferase.
  
 
 0.974
got2a
Aspartate aminotransferase.
  
 
 0.970
got1l1
Glutamic-oxaloacetic transaminase 1-like 1.
  
 
 0.951
hpdb
4-hydroxyphenylpyruvate dioxygenase.
     
  0.950
fah
Fumarylacetoacetase.
 
  
 0.949
F1QRA1_DANRE
Amine oxidase.
   
  0.932
mif
Macrophage migration inhibitory factor.
     
 0.897
got2b
Aspartate aminotransferase.
  
 
 0.889
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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