Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smyd5SMYD family member 5. (415 aa)    
Predicted Functional Partners:
smyd4
SET and MYND domain-containing 4.
      
 0.930
smyd3
SET and MYND domain-containing 3.
   
  
 0.917
smyd1b
SET and MYND domain-containing 1b.
      
 0.765
kmt2e
Lysine (K)-specific methyltransferase 2E.
    
 0.764
setd2
SET domain-containing 2, histone lysine methyltransferase.
     
 0.737
setd3
Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
   
  
 0.734
setd1a
SET domain-containing 1A, histone lysine methyltransferase.
    
 0.713
setd1ba
Histone-lysine N-methyltransferase SETD1B-A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
    
 0.712
setmar
SET domain and mariner transposase fusion protein.
     
 0.708
map3k2
Mitogen-activated protein kinase kinase kinase 2.
    
 
 0.705
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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