Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
arhgef18aRho/rac guanine nucleotide exchange factor (GEF) 18a. (940 aa)    
Predicted Functional Partners:
cgnb
Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Note=Localizes to the apical junction complex composed of tight and adherens junctions.
     
  0.973
rhoac
Rho-related GTP-binding protein RhoA-C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
    
  0.922
stk11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
     
  0.871
rhoab
Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
    
 0.843
f11r.1
F11 receptor, tandem duplicate 1.
   
 
  0.811
plekhg6
Pleckstrin homology domain-containing, family G (with RhoGef domain) member 6.
    
 0.770
rhocb
Rho-related GTP-binding protein RhoA-D; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
    
  0.768
rhoaa
Rho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
    
  0.768
ENSDARP00000131526
Si:dkey-92j12.5.
    
 0.746
patj
PATJ crumbs cell polarity complex component.
    
 0.746
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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