node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dusp6 | etv4 | ENSDARP00000095269 | ENSDARP00000016969 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | 0.750 |
dusp6 | fgf3 | ENSDARP00000095269 | ENSDARP00000132485 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. | 0.626 |
dusp6 | fgf8a | ENSDARP00000095269 | ENSDARP00000018653 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. | 0.836 |
dusp6 | fgfr1a | ENSDARP00000095269 | ENSDARP00000013742 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.758 |
dusp6 | fgfr2 | ENSDARP00000095269 | ENSDARP00000124472 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.590 |
dusp6 | spry1 | ENSDARP00000095269 | ENSDARP00000135575 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Sprouty homolog 1, antagonist of FGF-signaling (Drosophila). | 0.656 |
dusp6 | spry4 | ENSDARP00000095269 | ENSDARP00000090302 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Sprouty homolog 4 (Drosophila). | 0.860 |
etv4 | dusp6 | ENSDARP00000016969 | ENSDARP00000095269 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.750 |
etv4 | fgf10a | ENSDARP00000016969 | ENSDARP00000048580 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.750 |
etv4 | fgf3 | ENSDARP00000016969 | ENSDARP00000132485 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. | 0.749 |
etv4 | fgf8a | ENSDARP00000016969 | ENSDARP00000018653 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. | 0.813 |
etv4 | fgfr1a | ENSDARP00000016969 | ENSDARP00000013742 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] | 0.745 |
etv4 | fgfr2 | ENSDARP00000016969 | ENSDARP00000124472 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.645 |
etv4 | ncoa3 | ENSDARP00000016969 | ENSDARP00000102117 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Nuclear receptor coactivator 3. | 0.908 |
etv4 | pax2a | ENSDARP00000016969 | ENSDARP00000071466 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | 0.664 |
etv4 | spry1 | ENSDARP00000016969 | ENSDARP00000135575 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Sprouty homolog 1, antagonist of FGF-signaling (Drosophila). | 0.644 |
etv4 | spry4 | ENSDARP00000016969 | ENSDARP00000090302 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | Sprouty homolog 4 (Drosophila). | 0.815 |
fgf10a | etv4 | ENSDARP00000048580 | ENSDARP00000016969 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. | 0.750 |
fgf10a | fgf3 | ENSDARP00000048580 | ENSDARP00000132485 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. | 0.573 |
fgf10a | fgf8a | ENSDARP00000048580 | ENSDARP00000018653 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. | 0.682 |