Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mmp23bbMatrix metallopeptidase 23bb. (377 aa)    
Predicted Functional Partners:
LOC100001991
ADAM metallopeptidase with thrombospondin type 1 motif, 15b.
   
 
 0.694
LOC100002059
ADAM metallopeptidase with thrombospondin type 1 motif, 15b.
   
 
 0.690
noc2l
NOC2-like nucleolar-associated transcriptional repressor.
      
 0.683
ube2v1
Ubiquitin-conjugating enzyme E2 variant 1.
     
  0.628
supv3l1
ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation o [...]
    
 
 0.576
LOC568792
ADAM metallopeptidase with thrombospondin type 1 motif, 16.
   
 
 0.565
spint1b
Serine peptidase inhibitor, Kunitz type 1 b.
      
 0.558
ccl38a.4
C-C motif chemokine.
      
 0.552
loxl2a
Lysyl oxidase homolog 2A; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also medi [...]
    
 0.483
il12bb
Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.
      
 0.483
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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