Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
neflbNeurofilament, light polypeptide b; Belongs to the intermediate filament family. (579 aa)    
Predicted Functional Partners:
dusp12
Dual-specificity phosphatase 12.
    
 0.696
prph
Prph protein; Belongs to the intermediate filament family.
   
  0.693
slc35g2b
Solute carrier family 35 member G2b.
      
 0.681
GAN
Gigaxonin.
    
 
 0.635
dlg4
Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity.
    
 0.627
dlg2
Disks large homolog 2; May play a role in synapse assembly and function.
    
 0.627
grik1a
Glutamate receptor, ionotropic, kainate 1a.
   
 
 0.620
arr3b
Arrestin 3b, retinal (X-arrestin).
    
 
 0.604
camk2d2
Calcium/calmodulin-dependent protein kinase type II delta 2 chain; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.
   
 0.583
nes
Nestin; Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development.
    
 0.577
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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