Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
erp44Thioredoxin domain containing 4 (Endoplasmic reticulum). (408 aa)    
Predicted Functional Partners:
prdx4
Peroxiredoxin 4.
  
 
 0.912
ero1a
ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity). Belongs to the EROs family.
    
 0.895
ero1b
Endoplasmic reticulum oxidoreductase beta.
    
 0.849
dnajb11
DnaJ heat shock protein family (Hsp40) member B11.
   
 0.799
tgfb1a
Transforming growth factor beta; Belongs to the TGF-beta family.
    
   0.761
smarce1
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily e, member 1.
      
 0.761
tgfb1b
Transforming growth factor beta; Belongs to the TGF-beta family.
    
   0.761
sumf1
Sulfatase-modifying factor 1.
   
 
 0.733
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
      
 0.731
rpl13a
Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.
      
 0.701
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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