Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sgsm3Small G protein signaling modulator 3; Belongs to the small G protein signaling modulator family. (755 aa)    
Predicted Functional Partners:
ppwd1
Peptidylprolyl isomerase domain and WD repeat-containing 1.
    
   0.772
cog4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in the vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity); Belongs to the COG4 family.
    
   0.743
smim7
Small integral membrane protein 7.
    
   0.743
atp13a1
Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
      
 0.714
ntn5
Netrin 5.
      
 0.712
pelo
Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
   
  
 0.706
nubpl
Nucleotide-binding protein-like.
      
 0.703
ufsp2
Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins; Belongs to the peptidase C78 family.
      
 0.696
pdcd6ip
Programmed cell death 6-interacting protein.
   
   0.642
otud3
OTU deubiquitinase 3.
      
 0.631
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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