Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
igf1Insulin-like growth factor 1b. (161 aa)    
Predicted Functional Partners:
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.979
igfbp3
Insulin-like growth factor-binding protein 3.
   
 
 0.979
igf1rb
Tyrosine-protein kinase receptor.
     
 0.958
igf1ra
Tyrosine-protein kinase receptor.
     
 0.952
igf2b
Insulin-like growth factor 2b.
   
 
 
0.947
insrb
Tyrosine-protein kinase receptor.
     
 0.940
egf
Epidermal growth factor.
     
 0.939
insra
Tyrosine-protein kinase receptor.
     
 0.936
vegfaa
Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation.
     
 0.936
vegfc
Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.
     
 0.920
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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