pdx1 protein (Danio rerio) - STRING interaction network

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Score

pdx1

Pancreatic and duodenal homeobox 1. (246 aa)

Predicted Functional Partners:

ins

0.954

insb

0.909

ptf1a

0.852

mafaa

0.850

neurog3

0.841

gcgb

0.824

pax4

0.799

vps9d1

0.764

pcif1

0.757

neurod1

0.754

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
gcgb	ins	ENSDARP00000112837	ENSDARP00000051221	Glucagon b.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.993
gcgb	insb	ENSDARP00000112837	ENSDARP00000115146	Glucagon b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.991
gcgb	mafaa	ENSDARP00000112837	ENSDARP00000064832	Glucagon b.	Transcription factor MafAa; Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes. Specifically binds to the alphaCE2 enhancer element of crystallin gene.	0.468
gcgb	neurod1	ENSDARP00000112837	ENSDARP00000026490	Glucagon b.	Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.	0.689
gcgb	neurog3	ENSDARP00000112837	ENSDARP00000106489	Glucagon b.	Neurog3 protein.	0.835
gcgb	pax4	ENSDARP00000112837	ENSDARP00000013792	Glucagon b.	Paired box 4.	0.853
gcgb	pdx1	ENSDARP00000112837	ENSDARP00000017531	Glucagon b.	Pancreatic and duodenal homeobox 1.	0.824
gcgb	ptf1a	ENSDARP00000112837	ENSDARP00000011265	Glucagon b.	Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.	0.759
ins	gcgb	ENSDARP00000051221	ENSDARP00000112837	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon b.	0.993
ins	insb	ENSDARP00000051221	ENSDARP00000115146	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.813
ins	mafaa	ENSDARP00000051221	ENSDARP00000064832	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transcription factor MafAa; Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes. Specifically binds to the alphaCE2 enhancer element of crystallin gene.	0.504
ins	neurod1	ENSDARP00000051221	ENSDARP00000026490	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.	0.796
ins	neurog3	ENSDARP00000051221	ENSDARP00000106489	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurog3 protein.	0.845
ins	pax4	ENSDARP00000051221	ENSDARP00000013792	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Paired box 4.	0.828
ins	pdx1	ENSDARP00000051221	ENSDARP00000017531	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.954
ins	ptf1a	ENSDARP00000051221	ENSDARP00000011265	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.	0.828
insb	gcgb	ENSDARP00000115146	ENSDARP00000112837	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon b.	0.991
insb	ins	ENSDARP00000115146	ENSDARP00000051221	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.813
insb	mafaa	ENSDARP00000115146	ENSDARP00000064832	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Transcription factor MafAa; Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes. Specifically binds to the alphaCE2 enhancer element of crystallin gene.	0.422
insb	neurod1	ENSDARP00000115146	ENSDARP00000026490	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.	0.754

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