node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
foxa2 | ins | ENSDARP00000007827 | ENSDARP00000051221 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.685 |
foxa2 | insb | ENSDARP00000007827 | ENSDARP00000115146 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.650 |
foxa2 | isl1 | ENSDARP00000007827 | ENSDARP00000012903 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.719 |
foxa2 | neurod1 | ENSDARP00000007827 | ENSDARP00000026490 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. | 0.581 |
foxa2 | neurog3 | ENSDARP00000007827 | ENSDARP00000106489 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Neurog3 protein. | 0.686 |
foxa2 | pax4 | ENSDARP00000007827 | ENSDARP00000013792 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Paired box 4. | 0.616 |
foxa2 | pdx1 | ENSDARP00000007827 | ENSDARP00000017531 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Pancreatic and duodenal homeobox 1. | 0.674 |
foxa2 | ptf1a | ENSDARP00000007827 | ENSDARP00000011265 | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.616 |
gcgb | ins | ENSDARP00000112837 | ENSDARP00000051221 | Glucagon b. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.997 |
gcgb | insb | ENSDARP00000112837 | ENSDARP00000115146 | Glucagon b. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.993 |
gcgb | isl1 | ENSDARP00000112837 | ENSDARP00000012903 | Glucagon b. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.550 |
gcgb | neurod1 | ENSDARP00000112837 | ENSDARP00000026490 | Glucagon b. | Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. | 0.745 |
gcgb | neurog3 | ENSDARP00000112837 | ENSDARP00000106489 | Glucagon b. | Neurog3 protein. | 0.860 |
gcgb | pax4 | ENSDARP00000112837 | ENSDARP00000013792 | Glucagon b. | Paired box 4. | 0.861 |
gcgb | pdx1 | ENSDARP00000112837 | ENSDARP00000017531 | Glucagon b. | Pancreatic and duodenal homeobox 1. | 0.855 |
gcgb | ptf1a | ENSDARP00000112837 | ENSDARP00000011265 | Glucagon b. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. | 0.813 |
ins | foxa2 | ENSDARP00000051221 | ENSDARP00000007827 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. | 0.685 |
ins | gcgb | ENSDARP00000051221 | ENSDARP00000112837 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Glucagon b. | 0.997 |
ins | insb | ENSDARP00000051221 | ENSDARP00000115146 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.905 |
ins | isl1 | ENSDARP00000051221 | ENSDARP00000012903 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.694 |