Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
wdr5WD repeat domain 5. (334 aa)    
Predicted Functional Partners:
rbbp5
Retinoblastoma-binding protein 5.
   
0.999
ash2l
Ash2-like, histone lysine methyltransferase complex subunit.
   
 0.999
men1
Multiple endocrine neoplasia I.
    
 0.998
dpy30
Dpy-30 histone methyltransferase complex regulatory subunit.
   
 0.993
setd1ba
Histone-lysine N-methyltransferase SETD1B-A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
    
 0.990
setd1a
SET domain-containing 1A, histone lysine methyltransferase.
    
 0.987
cxxc1b
CXXC finger protein 1b.
    
 0.984
cxxc1a
CXXC finger protein 1a.
    
 0.979
kmt2d
Lysine (K)-specific methyltransferase 2D.
   
 0.977
setd1bb
SET domain-containing 1B, histone lysine methyltransferase b.
    
 0.976
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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