Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mmadhcMetabolism of cobalamin-associated D. (297 aa)    
Predicted Functional Partners:
mmachc
Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...]
    
 0.984
mmaa
Metabolism of cobalamin-associated A.
      
 0.955
zgc:92335
Zgc:92335.
     
  0.950
mmab
Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.
      
 0.948
mtr
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.865
mut
Methylmalonyl CoA mutase.
   
  
 0.830
mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase.
     
 0.809
gtdc1
Glycosyltransferase-like domain-containing protein 1; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
      
 0.806
mcee
Methylmalonyl CoA epimerase.
   
  
 0.765
lypd6b
LY6/PLAUR domain-containing 6B.
      
 0.749
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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