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asna1 protein (Danio rerio) - STRING interaction network
"asna1" - ATPase asna1 in Danio rerio
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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asna1ATPase asna1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (341 aa)    
Predicted Functional Partners:
sec62
SEC62 homolog, preprotein translocation factor; SEC62 homolog (S. cerevisiae) (394 aa)
     
  0.980
get4
Golgi to ER traffic protein 4 homolog (S. cerevisiae) (322 aa)
     
 
  0.968
sec61a1
Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development (476 aa)
     
  0.966
sec63
SEC63 homolog, protein translocation regulator; SEC63-like (S. cerevisiae) (751 aa)
     
  0.964
sec61b
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum (97 aa)
     
  0.958
wrb
Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane (170 aa)
     
 
  0.957
zgc:92744
Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (65 aa)
         
  0.940
sec61g
Sec61 gamma subunit (68 aa)
     
 
  0.912
camlg
Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B (262 aa)
       
 
  0.890
psmb6
Proteasome (prosome, macropain) subunit, beta type, 6 (232 aa)
     
 
  0.888
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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