STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
insig1Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (251 aa)    
Predicted Functional Partners:
scap
SREBF chaperone.
   
 
 0.944
hmgcra
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.900
srebf2
Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).
   
 
 0.873
hmgcrb
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.873
hsd17b7
Hydroxysteroid (17-beta) dehydrogenase 7.
   
  
 0.850
dhcr24
24-dehydrocholesterol reductase.
   
  
 0.840
chaf1b
Chromatin assembly factor 1, subunit B.
    
 
 0.837
srebf1
Sterol regulatory element-binding transcription factor 1.
   
 
 0.823
hmgcs1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.810
npc1
Niemann-Pick disease, type C1.
   
 
 0.759
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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