Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
akr1b1.1Aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1. (315 aa)    
Predicted Functional Partners:
aldh9a1b
4-trimethylaminobutyraldehyde dehydrogenase B; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
   
 0.932
sord
Sorbitol dehydrogenase.
  
 0.928
aldh3a1
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 0.906
aldh3a2a
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
   
 0.905
rgn
Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
  
 
 0.905
dhfr
Dihydrofolate reductase.
  
 
 0.902
aldh7a1
Aldehyde dehydrogenase 7 family, member A1; Belongs to the aldehyde dehydrogenase family.
   
 0.901
GK3P
Zgc:172295; Belongs to the FGGY kinase family.
  
 
 0.899
pah
Phenylalanine hydroxylase.
   
 
 0.898
DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
  
 
 0.893
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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