Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mdkbMidkine-related growth factor Mdk2. (147 aa)    
Predicted Functional Partners:
alk
Tyrosine-protein kinase receptor.
    
 0.958
pik3cb
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
     
 0.622
alkal1
ALK and LTK ligand 1.
     
 0.620
Sdc3
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
      
 0.611
ltk
Tyrosine-protein kinase receptor.
    
 
 0.604
ptn
Pleiotrophin.
  
 
0.598
ptprz1a
Protein tyrosine phosphatase receptor type Z1a.
    
 
 0.574
alkal2b
ALK and LTK ligand 2b.
     
 0.566
pik3r1
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).
     
 0.551
pik3r2
Phosphoinositide-3-kinase, regulatory subunit 2 (beta).
     
 0.551
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.