Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ppme1Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (377 aa)    
Predicted Functional Partners:
ppp2r2d
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...]
    
 
 0.979
ppp2r1bb
Protein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform.
   
 0.916
ppp2r1ba
Protein phosphatase 2, regulatory subunit A, beta a.
    
 0.914
ptpa
Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
   
 
 0.912
ppp2ca
Serine/threonine-protein phosphatase.
    
 0.901
ppp2cb
Serine/threonine-protein phosphatase.
    
 0.901
zgc:56064
Serine/threonine-protein phosphatase.
    
 
 0.843
mfhas1
Malignant fibrous histiocytoma-amplified sequence 1.
    
 0.835
ppp4r2a
Serine/threonine-protein phosphatase 4 regulatory subunit 2-A; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4C); Belongs to the PPP4R2 family.
    
 
 0.824
ppp4r2b
Serine/threonine-protein phosphatase 4 regulatory subunit 2-B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4); Belongs to the PPP4R2 family.
    
 
 0.824
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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