Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nkd2aProtein naked cuticle homolog 2-like; Cell autonomous antagonist of both the canonical and non- canonical Wnt signaling pathways; Belongs to the NKD family. (409 aa)    
Predicted Functional Partners:
dvl2
Dishevelled segment polarity protein 2.
    
 0.980
dvl3
Dishevelled segment polarity protein 3b.
    
 0.959
dvl3a
Dishevelled segment polarity protein 3a.
    
 0.954
nkd1
Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity); Belongs to the NKD family.
  
 
0.950
dvl1b
Dishevelled segment polarity protein 1b.
    
 0.948
dvl1a
Dishevelled segment polarity protein 1a.
    
 0.896
F8W5A4_DANRE
Si:ch73-236e11.2.
    
 0.896
LOC100500933
NKD inhibitor of WNT-signaling pathway 3.
     
  0.821
ywhae2
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.
    
   0.630
ywhae1
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family.
    
   0.630
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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