Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cass4Cas scaffold protein family member 4. (793 aa)    
Predicted Functional Partners:
inpp5d
Inositol polyphosphate-5-phosphatase D.
    
 
 0.841
crkl
V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.
    
 0.820
crk
V-crk sarcoma virus CT10 oncogene homolog (Avian).
    
 0.820
ptk2bb
Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 0.794
pxnb
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
    
 0.759
lpxn
Leupaxin.
    
 0.759
pxna
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
    
 0.759
madd
MAP-kinase-activating death domain.
   
  
 0.752
nme8
NME/NM23 family member 8; Belongs to the NDK family.
    
 0.748
sorl1
Sortilin-related receptor, L(DLR class) A repeats-containing.
      
 0.745
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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