Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ubr7Ubiquitin protein ligase E3 component n-recognin 7. (410 aa)    
Predicted Functional Partners:
nasp
Nuclear autoantigenic sperm protein (histone-binding).
   
 
 0.855
casp8ap2
Caspase 8-associated protein 2.
   
  
 0.805
prim1
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
  
 0.723
rnf181
E3 ubiquitin-protein ligase RNF181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
      
 0.718
ubr3
E3 ubiquitin-protein ligase ubr3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development. Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7.
      
 0.717
gins2
DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.
   
  
 0.712
F6NIE2_DANRE
Si:ch211-113e8.10.
      
 0.699
chaf1b
Chromatin assembly factor 1, subunit B.
      
 0.686
slbp
Stem-loop-binding protein.
   
  
 0.671
slbp2
Stem-loop-binding protein 2.
   
  
 0.666
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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