| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aadat | afmid | ENSDARP00000010437 | ENSDARP00000131858 | Aminoadipate aminotransferase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.967 |
| aadat | got1 | ENSDARP00000010437 | ENSDARP00000129948 | Aminoadipate aminotransferase. | Aspartate aminotransferase. | 0.784 |
| aadat | got2a | ENSDARP00000010437 | ENSDARP00000060165 | Aminoadipate aminotransferase. | Aspartate aminotransferase. | 0.779 |
| aadat | kmo | ENSDARP00000010437 | ENSDARP00000024051 | Aminoadipate aminotransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.980 |
| aadat | kyat1 | ENSDARP00000010437 | ENSDARP00000019368 | Aminoadipate aminotransferase. | Kynurenine aminotransferase 1. | 0.964 |
| aadat | kynu | ENSDARP00000010437 | ENSDARP00000150386 | Aminoadipate aminotransferase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.979 |
| afmid | aadat | ENSDARP00000131858 | ENSDARP00000010437 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Aminoadipate aminotransferase. | 0.967 |
| afmid | kmo | ENSDARP00000131858 | ENSDARP00000024051 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.997 |
| afmid | kyat1 | ENSDARP00000131858 | ENSDARP00000019368 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine aminotransferase 1. | 0.950 |
| afmid | kynu | ENSDARP00000131858 | ENSDARP00000150386 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.995 |
| ahcy | cth | ENSDARP00000002844 | ENSDARP00000117293 | S-adenosylhomocysteine hydrolase; Belongs to the adenosylhomocysteinase family. | Cystathionase (cystathionine gamma-lyase). | 0.965 |
| ahcy | got2a | ENSDARP00000002844 | ENSDARP00000060165 | S-adenosylhomocysteine hydrolase; Belongs to the adenosylhomocysteinase family. | Aspartate aminotransferase. | 0.414 |
| ahcy | kyat1 | ENSDARP00000002844 | ENSDARP00000019368 | S-adenosylhomocysteine hydrolase; Belongs to the adenosylhomocysteinase family. | Kynurenine aminotransferase 1. | 0.950 |
| cth | ahcy | ENSDARP00000117293 | ENSDARP00000002844 | Cystathionase (cystathionine gamma-lyase). | S-adenosylhomocysteine hydrolase; Belongs to the adenosylhomocysteinase family. | 0.965 |
| cth | gclm | ENSDARP00000117293 | ENSDARP00000023515 | Cystathionase (cystathionine gamma-lyase). | Glutamate-cysteine ligase, modifier subunit. | 0.913 |
| cth | got1 | ENSDARP00000117293 | ENSDARP00000129948 | Cystathionase (cystathionine gamma-lyase). | Aspartate aminotransferase. | 0.959 |
| cth | got2a | ENSDARP00000117293 | ENSDARP00000060165 | Cystathionase (cystathionine gamma-lyase). | Aspartate aminotransferase. | 0.966 |
| cth | kyat1 | ENSDARP00000117293 | ENSDARP00000019368 | Cystathionase (cystathionine gamma-lyase). | Kynurenine aminotransferase 1. | 0.960 |
| cth | txnrd3 | ENSDARP00000117293 | ENSDARP00000135844 | Cystathionase (cystathionine gamma-lyase). | Thioredoxin reductase 3. | 0.955 |
| gclm | cth | ENSDARP00000023515 | ENSDARP00000117293 | Glutamate-cysteine ligase, modifier subunit. | Cystathionase (cystathionine gamma-lyase). | 0.913 |